Explore selected publications and concise research summaries from our focus areas.
Terbinafine Induced Stevens Johnson Syndrome Toxic Epidermal Necrolysis Overlap Syndrome
Case Report - Asian Journal of Case Reports in Medicine and Health
SJS-TEN overlap syndrome is a very rare but severe cutaneous adverse drug reaction that is caused by terbinafine administration. The patient was suffering from vulvovaginal for which she was consuming terbinafine which led to the occurrence of cutaneous eruptions, across the right and left lower limbs, face, upper limbs, chest, back, arms, and abdomen, affecting almost the entire body covering 10-30% of the body surface which makes it to fall under the category of SJS-TEN overlap syndrome. Although considered safe terbinafine may lead to such severe adverse drug reactions, proper precautions need to be taken while prescribing it. Avoid the drug in patients with a history of any drug reactions. The main goal of this case report is to bring awareness among healthcare professionals, and to make them vigilant against such severe cutaneous drug reactions caused by terbinafine.
Synergistic antibacterial activity of green-synthesized Ag-Fe-Zn trimetallic nanocomposites using Tinospora cordifolia leaf extract
Research Article - ScienceDirect
Silver-iron-zinc trimetallic nanocomposites (Ag-Fe-Zn TMNCs) were synthesized via a one-step, eco-friendly process utilizing Tinospora cordifolia (TC) leaf green extract as a versatile multifunctional agent. Silver nitrate, iron oxide (III), and zinc nitrate served as precursor materials for the trimetallic nanocomposite formation. Comprehensive characterization was performed using XRD, UV-Vis, FTIR, FE-SEM, EDS, VSM, and Zetasizer. FTIR spectra confirmed the presence of bio-functional groups from the TC extract on the surface of the metal nanocomposites (MNPs), while SEM and XRD analyses confirmed the topology and multi-phase crystalline structure of the TMNCs, dominated by a cubic spinel ZnFe2O4 phase. Zetasizer results indicated enhanced colloidal stability for the TMNCs and VSM measurements demonstrated magnetic behaviour. The antimicrobial activity of the synthesized TMNCs was evaluated against Escherichia coli (EPEC) and probiotic Lactobacillus (Lb) through growth and viability assays, using Gentamicin as a reference standard antibiotic. The Ag-based bimetallic nanoparticles (BMNPs) and Ag-Fe-Zn TMNCs exhibited superior antibacterial activity compared to their monometallic counterparts, with 1:1:1 Ag-Fe-Zn TMNCs showing the strongest inhibition, likely due to enhanced synergistic interactions at the bacterial membrane interface. Notably, AgNPs, Ag-Zn BMNPs, Ag-Fe BMNPs, and Ag-Fe-Zn TMNCs demonstrated significant inhibitory effects against pathogenic EPEC and probiotic Lb, whereas FeNPs and Zn-Fe BMNPs selectively inhibited EPEC without affecting probiotic Lb. The Ag-Fe BMNPs and Ag-Fe-Zn TMNCs exhibit magnetic properties, suggesting potential for future exploration in targeted therapeutic applications in addition to their robust antibacterial activity. These findings highlight the potential of green-synthesized Ag-Fe-Zn TMNCs as potent, multifunctional agents for biomedical and antibacterial industrial applications.
Nanomaterials and Nanocomposites for Aerospace Applications
Publication - ResearchGate
The pursuit of advanced aeronautical systems is intrinsically linked to the development of next-generation materials that transcend the limitations of conventional alloys and composites. This chapter addresses this imperative by exploring the paradigm-shifting role of nanomaterial-based fibers, a class of materials where the strategic integration of nanoscale constituents like carbon nanotubes, graphene, and boron nitride nanosheets into fiber matrices yields unprecedented property enhancements. Moving beyond mere weight reduction, the discussion centers on how these fibers impart synergistic multifunctionality, combining exceptional specific strength, superior thermal resilience, and tailored electrical properties to critical aeronautical structures. The chapter provides a critical examination of synthesis pathways, structure-property relationships, and emergent applications, from lightweight airframes to intelligent thermal management systems. It also confronts the pivotal challenges of scalable manufacturing, economic viability, and nanomaterial dispersion uniformity that currently gate widespread adoption. Ultimately, this examination confirms that nanomaterial-based fibers are poised to fundamentally reshape the landscape of aeronautical engineering. Their integration promises to catalyze a new generation of aerospace vehicles, characterized by unprecedented levels of efficiency, intelligence, and longevity. These advanced materials provide the foundational toolkit for constructing airframes that are not merely lightweight but which actively contribute to vehicle performance through embedded functionalities, setting a new benchmark for what constitutes a high-performance structural material.
Sustainable Water Purification Using Green-Synthesized Nanoparticles: A Comparison Between Mono- and Bimetallic Nanoparticle Systems
Publication - ResearchGate
This review explores recent advancements in using environmentally benign monometallic nanoparticles (MMNPs) and bimetallic nanoparticles (BMNPs) for photocatalytic water purification, addressing the urgent need for sustainable solutions to global water scarcity. This study systematically analyzes how key photocatalysis variables, including nanocatalyst concentration, dye selection, and pollutant concentration, influence dye degradation outcomes. Standardized experimental conditions utilizing UV irradiation, 10 ppm, methylene blue (MB), and green synthesis routes were employed for comparative assessment. Results indicate that BMNPs, particularly Ag-Cu BMNPs composites, consistently outperform their MMNPs, achieving degradation rates between 90% and 99%, compared to 70%-85% for MMNPs. This superior performance is attributed to synergistic effects between the constituent metals. The review further highlights the advantages of plant-based synthesis methods, which offer a safer, more economical, and stable alternative to conventional chemical methods. By critically evaluating the potential of these NPs under controlled scenarios, this work underscores the transformative potential of engineering BMNPs in advancing next-generation water treatment technologies.
